Informace o projektu
Basic ketones and their derivatives as potential anti-infective and anti-tumor drugs
- Kód projektu
- MUNI/IGA/0932/2021
- Období řešení
- 1/2022 - 12/2022
- Investor / Programový rámec / typ projektu
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Masarykova univerzita
- Interní grantová agentura MU
- Fakulta / Pracoviště MU
- Farmaceutická fakulta
This research focus on basic derivatives of aromatic-aliphatic ketones, especially thiosemicarbazone and semicarbazone derivatives of acetophenone and their therapeutic importance. Basic ketones and their derivatives containing an azomethine group exhibit a wide range of biological activities, including the widespread application of their metal complexes. This fact leads to the targeting of mentioned substances as potential inhibitors of aminopeptidase N and tyrosine kinase.
Publikace
Počet publikací: 8
2023
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Aminopeptidase N as a potential drug target
51st Conference Synthesis and Analsis of Drugs, Book of Abstracts, rok: 2023
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Aminopeptidase N as a potential drug target
European Pharmaceutical Journal, rok: 2023, ročník: 70, vydání: s2, DOI
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SCHIFF BASES AS POTENTIAL THERAPEUTIC AGENTS
Rok: 2023, druh: Další prezentace na konferencích
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SCHIFF BASES AS POTENTIAL THERAPEUTIC AND ANTICANCER AGENTS
Rok: 2023, druh: Další prezentace na konferencích
2022
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Aminopeptidase N Inhibitors as Pointers for Overcoming Antitumor Treatment Resistance
International Journal of Molecular Sciences, rok: 2022, ročník: 23, vydání: 17, DOI
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Aromatic Schiff bases as aminopeptidase N inhibitors
Rok: 2022, druh: Konferenční abstrakty
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DETERMINATION OF INHIBITORY ACTIVITY OF AMINOPEPTIDASE N BY USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY
Rok: 2022, druh: Další prezentace na konferencích
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SCHIFF BASES AS POTENTIAL INHIBITORS OF AMINOPEPTIDASE N AS ANTICANCER AGENTS
Rok: 2022, druh: Další prezentace na konferencích