Informace o projektu
Asymmetric organocatalyzed hydroxymethylation of isoindolinones
- Kód projektu
- MUNI/IGA/0916/2021
- Období řešení
- 1/2022 - 12/2022
- Investor / Programový rámec / typ projektu
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Masarykova univerzita
- Interní grantová agentura MU
- Fakulta / Pracoviště MU
- Farmaceutická fakulta
We would like to identify a new organocatalytic system that will be applied to the stereoselective hydroxymethylation of isoindolinones affording compounds of medicinal chemistry interest. The additional research aim is to develop and study the aforementioned asymmetric process employing either novel or underexplored sources of anhydrous formaldehyde, which could eliminate the current experimental constraints of the reaction, i.e. low rate, poor stereoselectivity, and difficult reproducibility.
Publikace
Počet publikací: 5
2024
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Asymmetric Organocatalyzed Transfer Hydroxymethylation of Isoindolinones Using Formaldehyde Surrogates
Organic Letters, rok: 2024, ročník: 12, vydání: 26, DOI
2023
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Enantioselective hydroxymethylation of isoindolinones using bench-stable formaldehyde surrogates
Rok: 2023, druh: Další prezentace na konferencích
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Enantioselective trihalohydroxyalkylation of activated phenols
Rok: 2023, druh: Další prezentace na konferencích
2022
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BENCH-STABLE AND SOLUBLE FORMALDEHYDE SURROGATES IN ASYMMETRIC HYDROXYMETHYLATION OF ISOINDOLINONES
Rok: 2022, druh: Další prezentace na konferencích
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Enantioselective organocatalyzed trihaloalkylation of activated phenols
Rok: 2022, druh: Další prezentace na konferencích