RNDr. Stanislava Bezdíček Králová, Ph.D.
Assistant Professor, Faculty of Pharmacy
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BKralova Lab
From extreme environments to natural products
Our group studies the biodiversity, evolution and adaptive strategies of microorganisms from extreme environments, with a particular focus on Antarctic bacteria and their natural products. We investigate how environmental pressures shape microbial genomes, biosynthetic pathways and chemical interactions, and how specialized metabolites support survival, competition and cooperation.
Our work combines microbial cultivation, (meta)genomics, metabolomics, synthetic biology and bioactivity testing to connect microbial diversity with molecular function and potential applications. Our long-term goal is to translate this knowledge into the discovery and development of new compounds, enzymes and biosynthetic systems for biotechnological, biomedical and environmental applications
Antartic Microbial Biodiversity and Evolution
Characterizing microbial diversity, evolutionary relationships and adaptive traits across Antarctic ecosystems.
Characterizing microbial diversity, evolutionary relationships and adaptive traits across Antarctic ecosystems.
Cultivation of Microorganisms from Extreme Environments
Developing tailored media and cultivation strategies to isolate, maintain and activate metabolically diverse microorganisms from extreme habitats.
Genome-Guided Natural Product Discovery
Using comparative genomics and biosynthetic prioritisation to identify promising metabolites for targeted experimental characterization.
Synthetic Biology of Microbial Biosynthetic Pathways
Activating, expressing and engineering biosynthetic pathways to access compounds not produced under standard laboratory conditions.
Biosynthetic Pathway Evolution
Investigating how environmental pressures shape biosynthetic gene clusters, pathway diversification and chemical innovation in extremophiles.
Ecological Functions of Specialized Metabolites
Determining how natural products mediate competition, cooperation, metal acquisition, stress tolerance and microbial interactions.
Biotechnological and Biomedical Applications
Developing microbial compounds and biosynthetic systems as new antimicrobials and tools for biotechnology and biomedicine.
Group Leader
RNDr. Stanislava Bezdíček Králová, Ph.D.
Assistant Professor, Faculty of Pharmacy
| web: | https://www.kralova-research.com |
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Stanislava Bezdíček Králová is a microbiologist specialising in microorganisms from extreme environments and microbial natural products. She studies Antarctic microbial biodiversity, evolution and adaptation, with particular interest in how environmental pressures shape biosynthetic pathways and specialised metabolites. Her research combines cultivation and media development, (meta)genomics, bioinformatics, metabolomics, genetic engineering and bioactivity testing. Following an MSCA fellowship at the University of Vienna, she established an independent group at the Faculty of Pharmacy, Masaryk University, supported by MUNI’s MASH StG/CoG scheme. Her group studies the diversity and evolution of microbial biosynthetic systems and translates these insights into the discovery of new natural products, antimicrobials and biotechnologically relevant enzymes.
Team Members
Carlos Eduardo Madureira Trufen, MSc.
Researcher, Bioinformatician
Peter Špaček, MSc, BSc (Hons)
PhD candidate
Mgr. Katarína Brugošová
PhD candidate
Mgr. Jiří Sekerák
PhD candidate
Bc. Karolína Mikulenková
MSc student
Bc. Theodor Kutý
MSc student
Bc. Paulína Letková
MSc student
Get in Touch
Interested in research collaboration, scientific discussion, or learning more about our work?
Contact us
email: bezdicekkralovas@pharm.muni.cz
Department of Molecular Pharmacy
Faculty of Pharmacy
Masaryk University
Studentská 832/13
625 00 Brno-Bohunice