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Project information
Asymmetric organocatalyzed hydroxymethylation of isoindolinones

Project Identification
MUNI/IGA/0916/2021
Project Period
1/2022 - 12/2022
Investor / Pogramme / Project type
Masaryk University
  • Internal grant agency MU
MU Faculty or unit
Faculty of Pharmacy

We would like to identify a new organocatalytic system that will be applied to the stereoselective hydroxymethylation of isoindolinones affording compounds of medicinal chemistry interest. The additional research aim is to develop and study the aforementioned asymmetric process employing either novel or underexplored sources of anhydrous formaldehyde, which could eliminate the current experimental constraints of the reaction, i.e. low rate, poor stereoselectivity, and difficult reproducibility.

Publications

Total number of publications: 5

2024

2023

2022

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